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IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

Abstract Background Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers. Method This study investigated the effect and mechanism of IGF-1R in mediating the desensitization of hepatoc...

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Principais autores: Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou, Xiaolong Tang
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2023-01-01
סדרה:BMC Cancer
נושאים:
Insulin-like growth factor-1
Insulin-like growth factor-1 receptor
Sorafenib
Hepatocellular carcinoma
PI3K / akt, RAS / raf / ERK
Podophyllotoxin
גישה מקוונת:https://doi.org/10.1186/s12885-023-10561-7
תגים: הוספת תג
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