Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting
Deregulation of the Ras/Raf/MEK/ERK pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutica...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2014-06-01
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| Serier: | Frontiers in Oncology |
| Fag: | |
| Online adgang: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00160/full |
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