A Differential Depth Sequencing Method, SPRE‐Seq, for Enhancing Targeted Region Coverage in Hybridization Capture‐Based NGS

ABSTRACT Sequencing depth is a crucial parameter for variant calling accuracy and sensitivity. The trade‐off between sequencing breadth and depth is a well‐known limitation in capture‐based targeted next‐generation sequencing (NGS). Herein, we propose a differential depth sequencing method, SPRE‐Seq...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Hui‐Juan Chen, Bing Wang, Yi‐Ran Zhang, Xue‐Na Yao, Chun‐Yan Yang, He‐Nan Dong, Li‐Li Cai, Dong‐Jie Fan, Qi‐Ming Zhou
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Maximum Academic Press 2025-10-01
Цуврал:	Engineering in Life Sciences
Нөхцлүүд:	hybridization capture‐based next‐generation sequencing oligonucleotide probes sequencing depth
Онлайн хандалт:	https://doi.org/10.1002/elsc.70047
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!