UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination

Abstract Background Pathological cardiac hypertrophy frequently leads to heart failure (HF). UBA1, the key E1 ubiquitin-activating enzyme, initiates ubiquitin-proteasome signaling and contributes to various diseases, yet its mechanism in cardiac hypertrophy remains unclear. Methods Cardiac hypertrop...

Полное описание

Библиографические подробности

Главные авторы:	Qiu-Yue Lin, Wei-Jia Yu, Jia-Xin Li, Wen-Xi Jiang, Shu-Jing Liu, Hai-Lian Bi, Hui-Hua Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-03-01
Серии:	Cell Communication and Signaling
Предметы:	Cardiac hypertrophy UBA1 Autophagy ATG5 Ubiquitination
Online-ссылка:	https://doi.org/10.1186/s12964-026-02761-y
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