UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination
Abstract Background Pathological cardiac hypertrophy frequently leads to heart failure (HF). UBA1, the key E1 ubiquitin-activating enzyme, initiates ubiquitin-proteasome signaling and contributes to various diseases, yet its mechanism in cardiac hypertrophy remains unclear. Methods Cardiac hypertrop...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BMC
2026-03-01
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| Σειρά: | Cell Communication and Signaling |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1186/s12964-026-02761-y |
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