Clinical and pharmacogenomic predictors of survival in tamoxifen treated breast cancer female patients: a real-world study

Abstract Aim To investigate the impact of tamoxifen dose, CYP2D6 inhibitors, CYP2D6*4 genotype, and non-genetic parameters on the outcomes of tamoxifen treated female breast cancer patients. Method We retrospectively included 3218 female patients who initiated tamoxifen following a diagnosis of brea...

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Huvudupphov:	Abdullah R. Al-Matrafi, Khaled F. Bedair, Sundararajan Srinivasan, Colin Palmer, Archie Campbell, Caroline Hayward, Ewan R. Pearson, Russell D. Petty
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-06-01
Serie:	BMC Cancer
Ämnen:	Tamoxifen Breast Cancer CYP2D6 CYP2D6*4 CYP2D6 inhibitors SSRIs
Länkar:	https://doi.org/10.1186/s12885-025-14162-4
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