Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations

Abstract Background Epidermal remodeling and hypertrophy are hallmarks of skin fibrotic disorders, and keratinocyte to mesenchymal (EMT)-like transformations drive epidermis alteration in skin fibrosis such as keloids and hypertrophic scars (HTS). While phosphodiesterase 4 (PDE4) inhibitors have sho...

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主要な著者:	Javier Milara, Pilar Ribera, Severiano Marín, Paula Montero, Inés Roger, Julio Cortijo
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2024-09-01
シリーズ:	Molecular Medicine
主題:	Skin fibrosis Keloid Hypertrophic scar Phosphodiesterase 4
オンライン･アクセス:	https://doi.org/10.1186/s10020-024-00906-8
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