Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice

Zinc dyshomeostasis may trigger oxidative stress, which is likely the key mechanism of neuronal death in amyotrophic lateral sclerosis (ALS), including familial forms such as G93A SOD-1 ALS. Since zinc binding by G93A SOD-1 is weaker than by normal SOD-1, we assessed whether labile zinc levels are a...

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Autors principals:	Jean Kim, Tae-Youn Kim, Jung Jin Hwang, Joo-Yong Lee, Jin-Hee Shin, Byung Joo Gwag, Jae-Young Koh
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2009-05-01
Col·lecció:	Neurobiology of Disease
Matèries:	Excitotoxicity Motoneurons HNE Zinc chelator ALS
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996109000060
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