βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism

IntroductionSarcoidosis is a multisystem chronic inflammatory disorder of unknown etiology that primarily affects the lungs and currently has no cure. Macrophages are central to granuloma formation, and βc cytokines tightly regulate their activation and function. This study investigates the role of...

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Váldodahkkit:	Hao Wang, Damon J. Tumes, Simon Keam, Jia Wen Lim, Quynh Anh Nguyen, Ross Vlahos, Jonathan McQualter, Adam Quek, Carly Whyte, Harshita Pant, Timothy R. Hercus, Nicholas J. Wilson, Paul N. Reynolds, Catherine M. Owczarek, Angel F. Lopez, Steven Bozinovski, Kwok Ho Yip
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2025-12-01
Ráidu:	Frontiers in Immunology
Fáttát:	βc cytokines granulomas inflammation lipid metabolism macrophages sarcoidosis
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1733060/full
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