PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

Abstract Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7 expression, a protein highly express...

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Hlavní autoři:	Meneka Rupasinghe, Cristiana Bersaglieri, Deena M Leslie Pedrioli, Patrick GA Pedrioli, Martina Panatta, Michael O Hottiger, Paolo Cinelli, Raffaella Santoro
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2024-02-01
Edice:	EMBO Reports
Témata:	PRAMEL7 Cullin 2 NuRD UHRF1 Ground-state Pluripotency
On-line přístup:	https://doi.org/10.1038/s44319-024-00083-z
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