Deficiency of G1 regulators P53, P21<sup>Cip1 </sup>and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest
<p>Abstract</p> <p>Background</p> <p>TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be in...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2007-11-01
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| Serier: | BMC Cancer |
| Online adgang: | http://www.biomedcentral.com/1471-2407/7/215 |
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