Characterization of chimeric antigen receptor modified T cells expressing scFv-IL-13Rα2 after radiolabeling with 89Zirconium oxine for PET imaging

Abstract Background Chimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is associated with serious toxicities such as cytokine release syndrome (CRS) and neurotoxicity. The mechanism of these serious adverse events (SAEs) a...

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Autori principali:	Pamela Leland, Dhiraj Kumar, Sridhar Nimmagadda, Steven R. Bauer, Raj K. Puri, Bharat H. Joshi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-06-01
Serie:	Journal of Translational Medicine
Soggetti:	CAR-T Cells 89Zr Radioactivity PET
Accesso online:	https://doi.org/10.1186/s12967-023-04142-2
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