Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma

IntroductionChimeric antigen receptor T (CAR-T) cell therapy presents a promising treatment option for various cancers, including solid tumors. Carcinoembryonic antigen (CEA) is an attractive target due to its high expression in many tumors, particularly gastrointestinal cancers, while limited expre...

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Auteurs principaux:	Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-05-01
Collection:	Frontiers in Immunology
Sujets:	chimeric antigen receptor T cells carcinoembryonic antigen single-chain fragment variable affinity cell therapy
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182409/full
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