Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies are dependent upon designed transmembrane proteins to bind target antigens and stimulate an immune response. The success or failure of these CARs is only partially predictable, yet recent work has highlighted the importance of antigen binding...

Full description

Bibliographic Details

Main Authors:	Jonah Cheung, Shagun Wazir, David R. Bell, James N. Kochenderfer, Wayne A. Hendrickson, Philippe Youkharibache
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2023-04-01
Series:	Crystals
Subjects:	CAR-T cell immunotherapy chimeric antigen receptor VH-VL interface Ig domains
Online Access:	https://www.mdpi.com/2073-4352/13/4/710
Tags:	Add Tag No Tags, Be the first to tag this record!