Chromatin Remodeling in Patient‐Derived Colorectal Cancer Models

Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, the transcriptomic and chromatin accessibili...

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Autors principals:	Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-04-01
Col·lecció:	Advanced Science
Matèries:	ATAC‐seq, Colorectal Cancer (CRC) Patient‐Derived Models of Cancer (PDMC) Patient‐Derived Organoids (PDO) Patient‐Derived Xenografts (PDX)
Accés en línia:	https://doi.org/10.1002/advs.202303379
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