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Chromatin Remodeling in Patient‐Derived Colorectal Cancer Models

Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, the transcriptomic and chromatin accessibili...

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Autores principales: Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley 2024-04-01
Colección:Advanced Science
Materias:
ATAC‐seq, Colorectal Cancer (CRC)
Patient‐Derived Models of Cancer (PDMC)
Patient‐Derived Organoids (PDO)
Patient‐Derived Xenografts (PDX)
Acceso en línea:https://doi.org/10.1002/advs.202303379
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