Synovial transcriptome analysis reveals ShenTong ZhuYu Tang alleviates osteoarthritis by targeting MMP-9 and immune microenvironment

Abstract Background This study aimed to elucidate key molecular alterations in the osteoarthritis (OA) synovial microenvironment through transcriptomic analysis and to investigate the multi-target mechanisms of ShenTong ZhuYu Tang (STZYT) using network pharmacology and molecular docking. Methods We...

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Detalhes bibliográficos

Principais autores:	Tihong Liang, Bo Zhou, Changwen Gu, Guoxuan Peng, Xu Ning, Mingzhi Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
Colecção:	Journal of Orthopaedic Surgery and Research
Assuntos:	Osteoarthritis Synovial ShenTong ZhuYu tang Network pharmacology MMP-9
Acesso em linha:	https://doi.org/10.1186/s13018-025-06617-y
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