Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2017-12-01
Sarja:	eLife
Aiheet:	lipid droplet lipolysis hypoxia cancer metabolism fatty acid oxidation reactive oxygen species
Linkit:	https://elifesciences.org/articles/31132
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!