Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1...

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Hlavní autoři:	Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2017-12-01
Edice:	eLife
Témata:	lipid droplet lipolysis hypoxia cancer metabolism fatty acid oxidation reactive oxygen species
On-line přístup:	https://elifesciences.org/articles/31132
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