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Ultrasound Combined With Microbubbles Loading BDNF Retrovirus to Open Blood–Brain Barrier for Treatment of Alzheimer’s Disease

Background: Brain-derived nerve growth factor (BDNF) is a promising effective target for the treatment of Alzheimer’s disease (AD). BDNF, which has a high molecular weight, has difficulty in crossing the blood–brain barrier (BBB). The study aimed to prepare microbubbles loading brain-derived nerve g...

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Principais autores: Feng Wang, Xi-Xi Wei, Lian-Sheng Chang, Lei Dong, Yong-Ling Wang, Na-Na Li
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-03-01
Serier:Frontiers in Pharmacology
Fag:
cationic microbubbles
Alzheimer’s disease
retrovirus
BDNF
blood-brain barrier
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.615104/full
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