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Bimetallic mesoporous cerium and copper-based nanoplatform with stearoyl CoA desaturase inhibitor and indocyanine green co-delivery for synergistic pancreatic tumor suppression

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an unfavorable prognosis, with a combined five-year survival rate below 5 % across all diagnostic stages. Despite surgical advancements marginally improving survival outcomes, clinical efficacy remains suboptimal. Concurrently, chemodynamic...

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Main Authors: Ruihe Zheng, Yanan Yang, Peng Zhang, Xiaona Han, Minqin Huang, Yuxia Wu, Yuhang Li
Format: Artigo
Language:Inglês
Published: Elsevier 2025-09-01
Series:Materials & Design
Subjects:
CeCu bimetallic nanoplatform
SCD1 inhibitor
Tumor microenvironment
PTT amplified CDT
Synergistic tumor suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525008779
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