Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways

Abstract Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some behave aggressively, growing rapidly and invading surrounding tissues, with high rates of recurrence and resistance to therapy. Our aim was to establish patterns of genomic, transcriptomic and methyl...

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Asıl Yazarlar:	Keiko Taniguchi-Ponciano, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A. Chavez-Santoscoy, Ilan Remba-Shapiro, Gerardo Guinto, Erika Magallon-Gayon, Benjamin Telles-Ramirez, Rodrigo Ponce de Leon-Conconi, Sandra Vela-Patiño, Sergio Andonegui-Elguera, Amayrani Cano-Zaragoza, Florencia Martinez-Mendoza, Jacobo Kerbel, Marco Loza-Mejia, Juan Rodrigo-Salazar, Alonso Mendez-Perez, Cristina Aguilar-Flores, Antonieta Chavez-Gonzalez, Elenka Ortiz-Reyes, Erick Gomez-Apo, Laura C. Bonifaz, Daniel Marrero-Rodriguez, Moises Mercado
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	BMC 2024-08-01
Seri Bilgileri:	Acta Neuropathologica Communications
Konular:	PitNET Recurrent Aggressive Transcriptome Same patient Exome
Online Erişim:	https://doi.org/10.1186/s40478-024-01796-x
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