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Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways

Abstract Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some behave aggressively, growing rapidly and invading surrounding tissues, with high rates of recurrence and resistance to therapy. Our aim was to establish patterns of genomic, transcriptomic and methyl...

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Principais autores: Keiko Taniguchi-Ponciano, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A. Chavez-Santoscoy, Ilan Remba-Shapiro, Gerardo Guinto, Erika Magallon-Gayon, Benjamin Telles-Ramirez, Rodrigo Ponce de Leon-Conconi, Sandra Vela-Patiño, Sergio Andonegui-Elguera, Amayrani Cano-Zaragoza, Florencia Martinez-Mendoza, Jacobo Kerbel, Marco Loza-Mejia, Juan Rodrigo-Salazar, Alonso Mendez-Perez, Cristina Aguilar-Flores, Antonieta Chavez-Gonzalez, Elenka Ortiz-Reyes, Erick Gomez-Apo, Laura C. Bonifaz, Daniel Marrero-Rodriguez, Moises Mercado
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:Acta Neuropathologica Communications
Assuntos:
PitNET
Recurrent
Aggressive
Transcriptome
Same patient
Exome
Acesso em linha:https://doi.org/10.1186/s40478-024-01796-x
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