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Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype

ABSTRACT Hypermutation-driven evolution is a major contributor to antibiotic resistance in some bacterial pathogens, but its role in Klebsiella pneumoniae remains poorly defined. We analyzed 11 KPC-producing ST258 K. pneumoniae isolates collected serially over ~4 years from a host with persistent co...

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Main Authors: Shaoji Cheng, Cornelius J. Clancy, Giuseppe Fleres, Hassan Badrane, Matthew J. Culyba, Anthony Newbrough, Liang Chen, M. Hong Nguyen
Format: Artigo
Language:Inglês
Published: ASM 2026-09-01
Series:Antimicrobial Agents and Chemotherapy
Subjects:
hypermutator
DNA mismatch protein
MutH
carbapenem-resistant
Klebsiella pneumoniae
Online Access:https://journals.asm.org/doi/10.1128/aac.00189-26
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