A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestatic and metabolic diseases. However, dissimilarities...

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Autori principali:	Jan Freark de Boer, Esther Verkade, Niels L. Mulder, Hilde D. de Vries, Nicolette Huijkman, Martijn Koehorst, Theo Boer, Justina C. Wolters, Vincent W. Bloks, Bart van de Sluis, Folkert Kuipers
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2020-03-01
Serie:	Journal of Lipid Research
Soggetti:	liver humanized mouse model cholesterol transintestinal cholesterol excretion cytochrome P450 family 2 subfamily c polypeptide 70
Accesso online:	http://www.sciencedirect.com/science/article/pii/S002222752043514X
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