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Heart-Specific and Conditional Deletion of the <i>Immt</i> Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart Metabolism

Mitochondria comprise ~1/3rd of the volume of an adult ventricular cardiomyocyte. The gene <i>Immt</i> encodes the Mic60/Mitofilin protein that is hypothesized to organize the mitochondrial contact site and cristae organization system (MICOS) complex that generates mitochondrial cristae junctions be...

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Principais autores: Yasuhide Kuwabara, Caitlin Keezer, Suh-Chin J. Lin, Akanksha Rajput, Jeffery D. Molkentin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Cells
Fag:
mitochondria
cardiac hypertrophy
cardiomyocyte
metabolism
mitophagy
Online adgang:https://www.mdpi.com/2073-4409/15/6/505
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