Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death
Summary: We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular dise...
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| Principais autores: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2023-10-01
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| Serier: | iScience |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2589004223019934 |
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