Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death
Summary: We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular dise...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2023-10-01
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| Seri Bilgileri: | iScience |
| Konular: | |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S2589004223019934 |
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