Homogeneous shear distribution improves NK-92 cell cytotoxicity in a clinically relevant 2 L membrane-stirred bioreactor

The immortalized NK-92 cell line is widely used to study natural killer (NK) cell biology and develop immunotherapies. NK-92 cells exhibit strong cytotoxic activity against tumor and virus-infected cells and are often used as a functional surrogate for primary NK cells. Beyond research applications,...

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Hauptverfasser:	Valentin von Werz, Yasemin van Heuvel, Matthias Hadrbolec, Michael Wagner, Philipp Eibl, Florian Huber, Moritz Meyer, Patrick Bongartz, Christian Witz, Oliver Spadiut
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-03-01
Schriftenreihe:	Frontiers in Bioengineering and Biotechnology
Schlagworte:	bioreactor computational fluid dynamics fed-batch membrane stirrer NK-92 pitched-blade
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1804945/full
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