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Impact of CPPs on primary human NK cell CQAs during cell expansion – an experimental study using design of experiments

Human natural killer (NK) cells represent a promising leukocyte population for use in immune cell therapies. Hematologic as well as solid tumors have been shown to respond to treatment with autologous or allogeneic NK cells. Providing NK cells in sufficient quantity and quality (i.e., efficacy, safe...

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Principais autores: Gregor Mattert, Christiane Schaffer, Aleksander Szarzynski, Valentin von Werz, Oliver Spadiut, Ralf Pörtner, Werner Dammermann
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-07-01
coleção:Frontiers in Bioengineering and Biotechnology
Assuntos:
cytotoxicity
DoE
glucose
mathematical model
NK cells
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fbioe.2026.1849836/full
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