Potent inhibition of HIV-1 replication by a Tat mutant.
Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-e...
Gardado en:
| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS ONE |
| Acceso en liña: | http://europepmc.org/articles/PMC2768900?pdf=render |
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