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Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Abstract Advanced renal cell carcinoma (RCC) primarily relies on targeted and immune‐based therapies, yet these treatments often face limitations due to inefficacy and drug resistance. Branched‐chain α‐keto‐acid dehydrogenase kinase (BCKDK) has been implicated in promoting RCC metastasis, but its sp...

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Principais autores: Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-10-01
Serier:Advanced Science
Fag:
AKT phosphorylation
apoptosis
branched‐chain α keto‐acid dehydrogenase kinase
drug resistance
PDOs
Online adgang:https://doi.org/10.1002/advs.202411081
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