Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
Abstract Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challenging task in biocatalysis. In this study, iolS, an aldo–keto reductase from Bacillus...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BMC
2023-10-01
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| Σειρά: | Microbial Cell Factories |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1186/s12934-023-02225-9 |
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