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Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is an adult-onset, progressive ataxia. SCA3 presents with ataxia before any gross neuropathology. A feature of many cerebellar ataxias is aberrant cerebellar output that contributes to motor dysfunction. We examined whether abnormal cerebellar output was present...

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Autori principali: Kristin Mayoral-Palarz, Andreia Neves-Carvalho, Sara Duarte-Silva, Daniela Monteiro-Fernandes, Patrícia Maciel, Kamran Khodakhah
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2022-08-01
Serie:Disease Models & Mechanisms
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Accesso online:http://dmm.biologists.org/content/15/8/dmm049514
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