Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

Serine/arginine-rich splicing factor 2 (SRSF2) is a member of the SR protein family that is involved in both constitutive and alternative mRNA splicing. Mutations in SRSF2 gene are frequently reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It is imperative to understand...

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Bibliografiske detaljer

Principais autores:	So Masaki, Shun Ikeda, Asuka Hata, Yusuke Shiozawa, Ayana Kon, Seishi Ogawa, Kenji Suzuki, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoyuki Kataoka
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2019-04-01
Serier:	Frontiers in Genetics
Fag:	myelodysplastic syndrome splicing SRSF2 exonic splicing enhancer aberrant splicing EZH2 (enhancer of zeste homolog 2)
Online adgang:	https://www.frontiersin.org/article/10.3389/fgene.2019.00338/full
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