A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Abstract Bladder fibrosis represents a widespread global health challenge associated with substantial socioeconomic burden. To date, no effective therapeutic interventions are available to halt or reverse its progression. Small activating RNA (saRNA)‐based therapy has recently garnered increasing in...

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Автори:	Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2026-02-01
Серія:	Advanced Science
Предмети:	bladder fibrosis fibroblast sirtuin‐1 small‐activating RNA tetrahedral framework nucleic acid
Онлайн доступ:	https://doi.org/10.1002/advs.202519527
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A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

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