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A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Abstract Bladder fibrosis represents a widespread global health challenge associated with substantial socioeconomic burden. To date, no effective therapeutic interventions are available to halt or reverse its progression. Small activating RNA (saRNA)‐based therapy has recently garnered increasing in...

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Principais autores: Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-02-01
Serier:Advanced Science
Fag:
bladder fibrosis
fibroblast
sirtuin‐1
small‐activating RNA
tetrahedral framework nucleic acid
Online adgang:https://doi.org/10.1002/advs.202519527
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