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Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-κB activation. More recently, IKK has also been shown to repress RIPK1 dependent extrinsic cell death pathways by directly phosphorylating RIPK1 at serine 25. In T cells, IKK expression is essential for normal development in...

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Principais autores: Sam Blanchett, Yves Dondelinger, Alessandro Barbarulo, Mathieu J. M. Bertrand, Benedict Seddon
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2022-12-01
סדרה:Frontiers in Immunology
נושאים:
T cells
extrinsic cell death
RIPK1
IKK complex
TNF
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1067164/full
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