Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative stress and the activation of inflammatory mediators play outstanding roles in the development of DOX-induced kidney damage. This study aimed to i...

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Principais autores:	Sandy R. Botros, Asmaa I. Matouk, Amr Amin, Gehan H. Heeba
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2024-02-01
סדרה:	Frontiers in Pharmacology
נושאים:	doxorubicin nephrotoxicity incretins glucagon-like peptide-1 dipeptidyl peptidase-4 inhibitor
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1353029/full
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