Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative stress and the activation of inflammatory mediators play outstanding roles in the development of DOX-induced kidney damage. This study aimed to i...

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Autores principales:	Sandy R. Botros, Asmaa I. Matouk, Amr Amin, Gehan H. Heeba
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2024-02-01
Colección:	Frontiers in Pharmacology
Materias:	doxorubicin nephrotoxicity incretins glucagon-like peptide-1 dipeptidyl peptidase-4 inhibitor
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1353029/full
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