Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3

Abstract The deubiquitinase ubiquitin-specific protease 13 (USP13) has been implicated in various cancers, yet its precise molecular function and clinical significance in colorectal cancer (CRC) remain poorly defined. Here, we identify USP13 as a critical regulator of CRC progression through systema...

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主要な著者:	Si-yu Chang, Bo Gu, Yong Xiong, Meng-si Zhao, Le Li, Yi Liu, Bai-qi Wang, Guo-qing Li, Run-lei Du, Xiao-dong Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer 2025-11-01
シリーズ:	Molecular Biomedicine
主題:	Colorectal cancer USP13 MKK3 P38 MAPK signaling Deubiquitination Tumor progression
オンライン･アクセス:	https://doi.org/10.1186/s43556-025-00375-3
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