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FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However, lowering translational efficiency extends rather...

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Principais autores: Ineke Dhondt, Vladislav A. Petyuk, Huaihan Cai, Lieselot Vandemeulebroucke, Andy Vierstraete, Richard D. Smith, Geert Depuydt, Bart P. Braeckman
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-09-01
Serier:Cell Reports
Fag:
15N-metabolic labeling
aging
Caenorhabditis elegans
daf-2 mutant
protein turnover
FOXO/DAF-16
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124716310695
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