FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However, lowering translational efficiency extends rather...

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Hlavní autoři:	Ineke Dhondt, Vladislav A. Petyuk, Huaihan Cai, Lieselot Vandemeulebroucke, Andy Vierstraete, Richard D. Smith, Geert Depuydt, Bart P. Braeckman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2016-09-01
Edice:	Cell Reports
Témata:	15N-metabolic labeling aging Caenorhabditis elegans daf-2 mutant protein turnover FOXO/DAF-16
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124716310695
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