T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

Abstract M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals. We previously found that an M1R positive al...

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Autors principals:	Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2020-02-01
Col·lecció:	Pharmacology Research & Perspectives
Matèries:	cooperativity M1 muscarinic acetylcholine receptor positive allosteric modulator α‐synuclein
Accés en línia:	https://doi.org/10.1002/prp2.560
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