Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes

Abstract Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown, an...

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मुख्य लेखकों:	Qing Zhang, Mengen Xing, Zhengkai Bao, Lu Xu, Yang Bai, Wanqi Chen, Wenhao Pan, Fang Cai, Qunxian Wang, Shipeng Guo, Jing Zhang, Zhe Wang, Yili Wu, Yun Zhang, Jia-Da Li, Weihong Song
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Publishing Group 2024-03-01
श्रृंखला:	Signal Transduction and Targeted Therapy
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41392-024-01768-6
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