Neuroprotective potential of selenium nanoparticles and/or physical and mental activities against social isolation–induced depression in a rat model: inflammatory, oxidative stress, apoptotic, and neurotransmission modulatory pathways

BackgroundSocial isolation (SI), attributable to modern lifestyles and fast-growing technology, is a leading cause of depression. Selenium nanoparticles (Se-NPs) are neuroactive agents owing to their antioxidant and anti-inflammatory activities. Additionally, physical and mental activities (Ph&M...

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Prif Awduron:	Karema Abu-Elfotuh, Furqan Hashim Hussein, Roaa Hameed Alwaidh, Qutaiba A. Qasim, Layla A. Al-Kharashi, Fatma M. Mostafa, Enji Reda, Abdou Mohammed Ahmed Elsharkawy, Heba Abdelnaser Aboelsoud, Shaimaa R. Abdelmohsen, Magy R. Kozman, Nervana Mostafa Kamal Bayoumy, Yasmen F. Mahran, Abeer Altamimi, Khaled Ragab Abdelhakim, Ahmed M. E. Hamdan, Aliaa Osman Abou-Beih
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2026-07-01
Cyfres:	Frontiers in Pharmacology
Pynciau:	depression mental activity physical activity selenium nanoparticles social isolation
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1810142/full
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