The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome

Creatine provides cells with high-energy phosphates for the rapid reconstitution of hydrolyzed adenosine triphosphate. The eponymous creatine transporter (CRT1/SLC6A8) belongs to a family of solute carrier 6 (SLC6) proteins. The key role of CRT1 is to translocate creatine across tissue barriers and...

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Principais autores:	Clemens V. Farr, Ali El-Kasaby, Michael Freissmuth, Sonja Sucic
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-10-01
coleção:	Frontiers in Synaptic Neuroscience
Assuntos:	creatine intellectual disability creatine transporter 1 creatine transporter deficiency protein misfolding pharmacochaperoning
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnsyn.2020.588954/full
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