Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

Abstract Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (A1‐26, B1‐13, C1‐23) as Hs...

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Bibliografische Detailangaben

Hauptverfasser:	Dr. Peng Liu, Dr. Xiangling Chen, Dr. Jianming Zhu, Dr. Bo Li, Dr. Zhaoqiang Chen, Dr. Guimin Wang, Dr. Haiguo Sun, Dr. Zhijian Xu, Dr. Zhixin Zhao, Dr. Chen Zhou, Dr. Chengying Xie, Prof. Liguang Lou, Prof. Weiliang Zhu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley-VCH 2019-03-01
Schriftenreihe:	ChemistryOpen
Schlagworte:	autophagy Hsp72 Hsp90 inhibitor triazines antitumor activity
Online-Zugang:	https://doi.org/10.1002/open.201900055
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