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Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

Abstract Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (A1‐26, B1‐13, C1‐23) as Hs...

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Principais autores: Dr. Peng Liu, Dr. Xiangling Chen, Dr. Jianming Zhu, Dr. Bo Li, Dr. Zhaoqiang Chen, Dr. Guimin Wang, Dr. Haiguo Sun, Dr. Zhijian Xu, Dr. Zhixin Zhao, Dr. Chen Zhou, Dr. Chengying Xie, Prof. Liguang Lou, Prof. Weiliang Zhu
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley-VCH 2019-03-01
סדרה:ChemistryOpen
נושאים:
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
גישה מקוונת:https://doi.org/10.1002/open.201900055
תגים: הוספת תג
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