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KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST

Abstract Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC and GIST cells highly rely on KIT signal pathway. Clinically, about 80-90% of treatment-naive GIST patients harbor prima...

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Principais autores: Shishan Zhou, Omar Abdihamid, Fengbo Tan, Haiyan Zhou, Heli Liu, Zhi Li, Sheng Xiao, Bin Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Cell Communication and Signaling
Fag:
KIT mutations and expression
Gastrointestinal stromal tumor
Therapeutic targets
Imatinib resistance
Online adgang:https://doi.org/10.1186/s12964-023-01411-x
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